abstract：OBJECTIVES:Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) has become a standard clinical trials outcome for cognition, but has been recognized as deficient in areas including coverage of cognitive domains, sensitivity and standardization. Computerized test batteries may address some of these issues....

journal_title：Acta neurologica Scandinavica

authors： Wesnes K,Edgar C,Andreasen N,Annas P,Basun H,Lannfelt L,Zetterberg H,Blennow K,Minthon L

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:To evaluate pain, cervical range of motion (CROM) and cognitive symptoms as predictors for poor prognosis defined as sick leave 3 years later. MATERIAL AND METHODS:In 97 patients CROM, pain intensity and cognitive symptoms were measured immediately following trauma, at 6 months and 3 years. Patients were al...

journal_title：Acta neurologica Scandinavica

authors： Borenstein P,Rosenfeld M,Gunnarsson R

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera. SUBJECTS AND METHODS:The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibit...

journal_title：Acta neurologica Scandinavica

authors： Rinta S,Airas L,Elovaara I

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between C-reactive protein (CRP)-values in the acute phase of stroke and the risk of further fatal and non-fatal ischemic events. MATERIALS AND METHODS:We analysed 462 consecutive incident ischemic strokes. Patients were divided into two subgroups on the basis of a CRP cut-o...

journal_title：Acta neurologica Scandinavica

authors： Corso G,Bottacchi E,Brusa A,Benedetto MD,Giardini G,Lia C,Reggiani M,Veronese Morosini M

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the progression of cognitive dysfunction in primary Sjögren Syndrome (SS). METHODS:Twelve subjects with SS were compared with ten subjects with migraine and ten healthy controls on neuropsychological, mood and fatigue tests at baseline and 8 years later. RESULTS:At fol...

journal_title：Acta neurologica Scandinavica

authors： Martínez S,Cáceres C,Mataró M,Escudero D,Latorre P,Dávalos A

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:The well-being and physical function among patients with ALS and their next of kin was studied over time. MATERIALS AND METHODS:Thirty-five patients with ALS and their next of kin were studied with respect to physical, general and psychological well-being by the visual analogue scale (VAS) every 4-6 months....

journal_title：Acta neurologica Scandinavica

authors： Olsson AG,Markhede I,Strang S,Persson LI

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain. MATERIALS AND METHODS:Several days after MR-compatible cannula placement in right basolateral amygdala, anesthetized rats were imaged at 7 T. R...

journal_title：Acta neurologica Scandinavica

authors： Munasinghe JP,Banerjee M,Acosta MT,Banks M,Heffer A,Silva AC,Koretsky A,Theodore WH

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The role of electromyography (EMG) recorded from the external anal sphincter (EAS) in the diagnosis of atypical parkinsonian syndromes is a matter for continuous debate. Most studies addressing this issue are retrospective. METHODS:In this study, we prospectively investigated six patients with Parkinson's D...

journal_title：Acta neurologica Scandinavica

authors： Winge K,Jennum P,Lokkegaard A,Werdelin L

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Subjective feelings of memory decline are fairly common among the elderly. The causes of this are heterogeneous, and may be related to both affective and cognitive disorders. We attempted to explore the associations between subjective and cognitive measures. MATERIALS AND METHODS:Healthy subjects were studi...

journal_title：Acta neurologica Scandinavica

authors： Balash Y,Mordechovich M,Shabtai H,Merims D,Giladi N

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available. The aim of this study is to characterize the therapeutic dose of valproate in children with newly diagnosed IGE. MATERIALS AND METHODS:Effect of...

journal_title：Acta neurologica Scandinavica

authors： Holland KD,Monahan S,Morita D,Vartzelis G,Glauser TA

更新日期：2010-03-01 00:00:00

abstract：:Treatment with intraventricular pentosan polysulphate (PPS) might be beneficial in patients with Creutzfeldt-Jakob disease. We report a 68-year-old woman with sporadic Creutzfeldt-Jakob disease who received continuous intraventricular PPS infusion (1-120 microg/kg/day) for 17 months starting 10 months after the onset ...

journal_title：Acta neurologica Scandinavica

authors： Terada T,Tsuboi Y,Obi T,Doh-ura K,Murayama S,Kitamoto T,Yamada T,Mizoguchi K

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:There has been a long-standing interest in the possible role of the hippocampus in autism and both postmortem brain and neuroimaging studies have documented varying abnormalities in this limbic system structure. AIMS:This study investigates the density of subsets of hippocampal interneurons, immunostained w...

journal_title：Acta neurologica Scandinavica

authors： Lawrence YA,Kemper TL,Bauman ML,Blatt GJ

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. MATERIALS AND METHODS:Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birt...

journal_title：Acta neurologica Scandinavica

authors： Salzer J,Svenningsson A,Sundström P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:The aim of this open label pilot study was to evaluate the efficacy and tolerability of levetiracetam (LEV) as 'de novo' monotherapy in children and adolescents with late onset childhood occipital epilepsy-Gastaut type (COE-G). MATERIAL AND METHODS:Twelve patients suffering from COE-G were enrolled in this ...

journal_title：Acta neurologica Scandinavica

authors： Verrotti A,Parisi P,Loiacono G,Mohn A,Grosso S,Balestri P,Tozzi E,Iannetti P,Chiarelli F,Curatolo P

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:We wanted to describe the use of thrombolytic treatment for stroke in Scandinavia, to assess stroke doctors' opinions on this treatment, to identify barriers against treatment, and to suggest improvements to overcome these barriers. METHODS:We sent questionnaires to 493 Scandinavian doctors, who were involve...

journal_title：Acta neurologica Scandinavica

authors： Slot KB,Murray V,Boysen G,Berge E

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala an...

journal_title：Acta neurologica Scandinavica

authors： Schultz RR,de Castro CC,Bertolucci PH

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. There is evidence that oxidative stress is implicated in the pathophysiology of the neurodegenerative disorders, including ALS. Data from the literature suggests that the receptor for advanced glycation end products (RAGE) partic...

journal_title：Acta neurologica Scandinavica

authors： Iłzecka J

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Far from being uniform, Huntington's disease (HD)'s phenotype encompasses a large variety of motor and non-motor symptoms which occur in various combinations in individual patients. AIM:To describe an unusual association between restless legs syndrome (RLS) and HD. METHODS AND RESULTS:We report a patient w...

journal_title：Acta neurologica Scandinavica

authors： Savva E,Schnorf H,Burkhard PR

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Understanding how antiepileptic (AED) monotherapy influences normative test scores is of importance in the clinic for correct interpretation of neuropsychological profiles. Previous studies have primarily reported minor influence on neuropsychological raw scores, and the clinical relevance of these findings ...

journal_title：Acta neurologica Scandinavica

authors： Hessen E,Lossius MI,Gjerstad L

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To examine, in a randomized, controlled, single blinded trial, the efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome (CTS). METHODS:We randomized 120 patients with CTS into a group wearing the soft hand brace MANU and into another group wearing the wrist splint CAMP TIELLE at night ...

journal_title：Acta neurologica Scandinavica

authors： De Angelis MV,Pierfelice F,Di Giovanni P,Staniscia T,Uncini A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment. MATERIALS AND METHODS:Patients with SE or ARS were treated in a consecutive manner with either VPA or PH...

journal_title：Acta neurologica Scandinavica

authors： Gilad R,Izkovitz N,Dabby R,Rapoport A,Sadeh M,Weller B,Lampl Y

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To describe clinical, electrophysiological and genetic data of five unrelated Sicilian pedigrees harbouring a heterozygous Ser78Leu mutation in the myelin protein zero (MPZ) extracellular domain. MATERIALS AND METHODS:Clinical, electrophysiological and genetic findings of 16 patients were reported. Polymorp...

journal_title：Acta neurologica Scandinavica

authors： Mazzeo A,Muglia M,Rodolico C,Toscano A,Patitucci A,Quattrone A,Messina C,Vita G

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:We evaluated the expression of chemokine-like factor (CKLF) in biopsied muscle fibers in inflammatory myopathies, non-inflammatory myopathies and neurologically diseased controls. MATERIALS AND METHODS:We studied the expression of CKLF in 15 polymyositis (PM), five dermatomyositis (DM), 15 non-inflammatory ...

journal_title：Acta neurologica Scandinavica

authors： Chowdhury MH,Nagai A,Terashima M,Sheikh A,Murakawa Y,Kobayashi S,Yamaguchi S

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Genomic analysis using microarray tools has the potential benefit of enhancing our understanding of neurological diseases. The analysis of these data is complex due to the large amount of data generated. Many tools have been developed to assist with this, but standard methods of analysis of these tools have ...

journal_title：Acta neurologica Scandinavica

authors： Hershey AD,Burdine D,Liu C,Nick TG,Gilbert DL,Glauser TA

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The Multiple Sclerosis Functional Composite (MSFC) is a multidimensional measurement tool for multiple sclerosis (MS) including a measure of ambulation (Timed 25-foot Walk [TWT]), arm function (Nine-Hole Peg Test [9HPT]) and cognition (Paced Auditory Serial Addition Test [PASAT]). OBJECTIVES:To assess the r...

journal_title：Acta neurologica Scandinavica

authors： Rosti-Otajärvi E,Hämäläinen P,Koivisto K,Hokkanen L

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:To study migraine without aura (MwoA) prevalence in the commune of Vågå, Norway; 1838 (18- to 65-year-old) individuals were included. A special search was made for cervicogenic characteristics in MwoA, as it has been claimed that such characteristics may frequently be present. A comparison with cervicogenic ...

journal_title：Acta neurologica Scandinavica

authors： Sjaastad O,Bakketeig LS

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Parkinson's disease (PD) may be associated with increased energy metabolism in overactive regions of the basal ganglia. Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) and oxygen metabolism in the...

journal_title：Acta neurologica Scandinavica

authors： Borghammer P,Vafaee M,Ostergaard K,Rodell A,Bailey C,Cumming P

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To describe successful treatment of tardive dyskinesia with levetiracetam. BACKGROUND:Tardive dyskinesia is a late-onset movement disorder caused by exposure to dopamine receptor blocking agents, most commonly neuroleptics. Metoclopramide is frequently used to treat gastrointestinal dysmotility. It has antid...

journal_title：Acta neurologica Scandinavica

authors： Zivković SA,Costa G,Bond G,Abu-Elmagd KM

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:We investigated executive function in Parkinson's disease (PD) patients, and focused on executive dysfunction in PD with hallucinations, but without dementia. METHODS:PD patients were classified by cognitive or neuropsychotic status as PD group, PD with vivid dreaming group, PD with hallucinations group and ...

journal_title：Acta neurologica Scandinavica

authors： Imamura K,Wada-Isoe K,Kitayama M,Nakashima K

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:To measure clinical and immunological parameters in a patient with myasthenia gravis (MG) treated with antibodies against CD25 (basiliximab, Simulect). Patient and methods - Injections of basiliximab were given repeatedly together with cyclosporin A and corticosteroids for 9 months to a patient with severe M...

journal_title：Acta neurologica Scandinavica

authors： Kakoulidou M,Pirskanen-Matell R,Lefvert AK

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but the relationship between the virus and the disease is not clear. As many different types of EBV exist, it is possible that MS is caused by one particular type of EBV. Objectives - The aim of this study was to determine whether...

journal_title：Acta neurologica Scandinavica

authors： Lindsey JW,Patel S,Zou J

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Variants in genes encoding enzymes involved in production, aggregation or degradation of beta-amyloid are potential risk factors for sporadic Alzheimer's disease (AD). METHODS:Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17T...

journal_title：Acta neurologica Scandinavica

authors： Llorca J,Rodríguez-Rodríguez E,Dierssen-Sotos T,Delgado-Rodríguez M,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00

abstract：:Anti-muscle-specific receptor tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) patients show various responses to conventional immunosuppressive treatment and some patients are resistant to these therapies. We report a 50-year-old Japanese man with anti-MuSK antibody-positive MG, who showed no or poor r...

journal_title：Acta neurologica Scandinavica

authors： Shibata-Hamaguchi A,Samuraki M,Furui E,Iwasa K,Yoshikawa H,Hayashi S,Yamada M

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Given the common features of neurodegeneration in multiple sclerosis (MS), FTD and ALS, sequence variants of the DCTN1 gene...

journal_title：Acta neurologica Scandinavica

authors： Münch C,Meyer R,Linke P,Meyer T,Ludolph AC,Haas J,Hemmer B

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. OBJECTIVE:The present study was designed ...

journal_title：Acta neurologica Scandinavica

authors： H-Stenstam B,Pellettieri L,Sköld K,Rezaei A,Brun A

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Valproic acid (VPA) may induce hyperammonemic encephalopathy. On the other hand, seizure-inducing effects of antiepileptic drugs (AEDs) may be a paradoxical reaction or a result of AED-induced encephalopathy (commonly induced by VPA). METHODS:We present the case of a 19-year-old male who developed acute men...

journal_title：Acta neurologica Scandinavica

authors： Velioğlu SK,Gazioğlu S

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:To examine the factors that influence acute and total length of stay (LOS) for stroke patients. MATERIALS AND METHODS:The basis of this investigation was a population-based cohort of first-ever stroke patients (n = 388). Subjects were survivors of the initial hospitalization (n = 295). Age, sex, social fact...

journal_title：Acta neurologica Scandinavica

authors： Appelros P

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Carotid intimal medial thickening (c-IMT) is an established surrogate marker for atherosclerosis. There have been sporadic reports about an increase of c-IMT on the left carotid artery among populations with a mean age of +/-50 years. OBJECTIVE:The purpose of this study was to evaluate whether there is a di...

journal_title：Acta neurologica Scandinavica

authors： Arbel Y,Maharshak N,Gal-Oz A,Shapira I,Berliner S,Bornstein NM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The present study focused on human leukocyte antigen (HLA) DQB1, DQA1 and DRB1 allelic variation according to ethnicity and analyzed whether susceptibility to multiple sclerosis (MS) depends on population characteristics. METHODS:Eighty-eight healthy African-Brazilians and 92 healthy white Brazilians living ...

journal_title：Acta neurologica Scandinavica

authors： Alves-Leon SV,Papais-Alvarenga R,Magalhães M,Alvarenga M,Thuler LC,Fernández y Fernandez O

更新日期：2007-05-01 00:00:00

abstract：:Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending SE, established SE, and subtle SE. We discuss the physiological and biochemical cascades which characterize self-...

journal_title：Acta neurologica Scandinavica

authors： Chen JW,Naylor DE,Wasterlain CG

更新日期：2007-04-01 00:00:00